Palladium-Catalyzed Polyfluorophenylation of Porphyrins with Bis(polyfluorophenyl)zinc Reagents

Catalysts

Noriaki Sugita¹  Satoshi Hayashi¹  Sawa Ishii¹ 

[1] Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan;

关键词: porphyrin;    polyfluorophenylation;    bis(polyfluorophenyl)zinc;    palladium;    cross-coupling;   

DOI  :  10.3390/catal3040839

来源: mdpi

【 摘 要 】

A facile and efficient method for the synthesis of pentafluorophenyl- and related polyfluorophenyl-substituted porphyrins has been achieved via palladium-catalyzed cross-coupling reactions of brominated porphyrins with bis(polyfluorophenyl)zinc reagents. The reaction is applicable to a variety of free-base bromoporphyrins, their metal complexes, and a number of bis(polyfluorophenyl)zinc reagents.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.