Effects of ginsenosides on memory impairment in propofol-anesthetized rats

Bioengineered

Zhou-Liang Xu¹  GanLu Chen¹  YongGan Ying¹  DaoFen Xie¹  XiangFei Liu¹  Jie Zhang² 

[1] Li Huili Hospital of Ningbo Medical Center;The Hospital Affiliated to Medical School of Yangzhou University (Taizhou People’s Hospital);

关键词: anesthesia;    ginsenosides;    memory impairment;    propofol;    water maze test;    y-maze test;   

DOI  :  10.1080/21655979.2021.2012407

来源: DOAJ

【 摘 要 】

To investigate the effects of ginsenosides on the memory impairment in Sprague–Dawley rats (SD rats) after anesthesia through the administration of propofol SPF, SD rats were randomly divided into four groups: control group (Group I), propofol-treated group (Group II), low dose of ginsenosides-treated group (Group III) and high dose of ginsenosides-treated group (Group IV). These rats were subjected to fear memory test in shuttle box, Y-maze test and Morris water maze test. Immediately after the test, the expression levels of nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) were further detected by ELISA method. Ginsenosides could ameliorate the impairment on the functions of fear memory, working memory and spatial memory in rats caused by anesthesia via the injection of Propofol. Furthermore, the expression levels of NGF and BDNF on rat hippocampus were significant increased by the treatment of ginsenosides at both two doses compared with the control group (both P < 0.05). Ginsenosides hold potential to be developed as a novel therapeutic agent for those patients suffering from postoperative cognitive dysfunction caused by anesthesia via the treatment of propofol.

【 授权许可】

Unknown