The use of methylphenidate for emergence from propofol and ketamine anesthesia in dogs

Iranian Journal of Veterinary Medicine

Reza Avizeh¹  Hadi Imani Rastabi¹  Narges Kavosi¹  Soroush Sabiza¹ 

[1] Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran;

关键词: anesthesia;    emergence;    ketamine;    methylphenidate;    propofol;   

DOI  :  10.22059/ijvm.2018.238819.1004829

来源: DOAJ

【 摘 要 】

Background: Methylphenidate (MPH) has been used to induce emergence from general anesthesia. OBJECTIVES:  The objective of the present study was to evaluate the effect of MPH on recovery from propofol and ketamine anesthesia in dogs. METHODS: Six healthy male mix-breed dogs weighing 21.9 ± 3.9 kg were used in a randomized crossover design. Thirty minutes after premedication with acepromazine (0.1 mg/kg; IM), anesthesia was induced with either IV propofol or ketamine (8 and 15 mg/kg, respectively). Dogs, six minutes after induction, received either IV normal saline or methylphenidate (1 mg/kg) (propofol-saline; propofol-methylphenidate; ketamine-saline; ketamine-methylphenidate). Each dog was anesthetized four times randomly with at least one week interval. RESULTS: No significant differences were observed between propofol-saline and propofol-methylphenidate as well as between ketamine-saline and ketamine-methylphenidate in the times needed for various chronological sequences of recovery (p>0.05). Recovery in the dogs that received methylphenidate was eventful and associated with some adverse effects. Heart rate showed a decrease in propofol-methylphenidate group compared to the base (p<0.05). Respiratory rate after administration of methylphenidate was more stable than that of saline. CONCLUSIONS: It was concluded that methylphenidate at 1 mg/kg could not shorten recovery time in the dogs premedicated with acepromazine and anesthetized with either propofol or ketamine. Testing lower doses of methylphenidate and using a different premedication agent are recommended for future studies.

【 授权许可】

Unknown