An Efficient Synthesis of Arylated Pyridines from Conjugated Acetylenes and Substituted Benzylamines Catalyzed by Base

Molecules

Mengping Guo¹  Bo Chen¹  Hua Jin¹  Qiuling Peng¹  Yanping Kang¹  Qiming Zhu¹ 

[1] College of Chemistry and Bio-Engineering, Yichun University, Yichun 336000, Jiangxi, China;

关键词: arylated pyridines;    synthesis;    transition-metal-free;    base;    catalysis;   

DOI  :  10.3390/molecules22081277

来源: DOAJ

【 摘 要 】

An efficient base-catalyzed synthesis of arylated pyridines has been disclosed. This reaction involving conjugated acetylenes and substituted benzylamines proceeded smoothly, giving rise to tri-aryl substituted pyridines which are biologically relevant compounds in good to excellent yields in N,N-dimethylformamide (DMF) under air at 140 °C with K2CO3 as catalyst.

【 授权许可】

Unknown