Studies on Jackfruit–Okra Mucilage-Based Curcumin Mucoadhesive Tablet for Colon Targeted Delivery

Frontiers in Pharmacology

Arul Prakash Francis¹  Shah Alam Khan²  Dhanalekshmi Unnikrishnan Meenakshi²  Mohd. Imran³  Kishore Narra⁴  Raha Orfali⁵  Syed Mohammed Basheeruddin Asdaq⁶  Pallavi Kurra⁷  Srinivasa Babu Puttugunta⁷ 

[1] Centre of Molecular Medicine and Diagnostics (COMManD), Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, India;College of Pharmacy, National University of Science and Technology, Muscat, Oman;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha, Saudi Arabia;Department of Pharmaceutical Technology, BIT Campus, Anna University, Tiruchirappalli, India;Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia;Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia;Vignan Pharmacy College, Gundur, India;

关键词: Curcumin;    mucilage;    jack fruit;    okra gum;    mucoadhesive;   

DOI  :  10.3389/fphar.2022.902207

来源: DOAJ

【 摘 要 】

The present work investigates a blend of jack fruit mucilage (JFM) and okra mucilage (OKM) as promising mucoadhesive carriers for colon-specific delivery of a curcumin (CMN)-loaded mucoadhesive tablet (CMT) formulation. Formulation optimization was performed using central composite design (CCD) to further decipher the effect of varying proportions of the mucoadhesive carriers JFM and OKG on response factors such as drug release (% DR) and mucoadhesive strength (MA). The optimized formulation CMT (F14) demonstrated a favorable 54.35% in vitro release of CMN in 12 h with release kinetics resulting from a zero-order anomalous diffusion mechanism and MA of 34.1733 ± 1.26 g. Accelerated stability testing of CMT (F14) confirmed a shelf life of about 4.7 years. In vivo drug targeting studies performed using rabbit models in order to observe transit behavior (colon-specific delivery) of the dosage form were assessed by fluoroscopic images of the GI tract. Taking the results together, the results confirm that the combination of JFM and OKM could be exploited as an ideal mucoadhesive carrier for effective delivery of macromolecules to the colon.

【 授权许可】

Unknown