Gold-Catalyzed Homogeneous (Cyclo)Isomerization Reactions

Frontiers in Chemistry

关键词: gold;    catalysis;    isomerization;    allenes;    1, n-enynes;    1, n-diynes;   

DOI  :  10.3389/fchem.2019.00296

来源: DOAJ

【 摘 要 】

Gold is currently one of the most used metals in organometallic catalysis. The ability of gold to activate unsaturated groups in different modes, together with its tolerance to a wide range of functional groups and reaction conditions, turns gold-based complexes into efficient and highly sought after catalysts. Natural products and relevant compounds with biological and pharmaceutical activity are often characterized by complex molecular structures. (Cyclo)isomerization reactions are often a useful strategy for the generation of this molecular complexity from synthetically accessible reactants. In this review, we collect the most recent contributions in which gold(I)- and/or gold(III)-catalysts mediate intramolecular (cyclo)isomerization transformations of unsaturated species, which commonly feature allene or alkyne motifs, and organize them depending on the substrate and the reaction type.

【 授权许可】

Unknown