Strategies for Articular Cartilage Repair and Regeneration

Frontiers in Bioengineering and Biotechnology

Karan M. Shah¹  Yanxi Liu²  Jian Luo³ 

[1] Department of Oncology and Metabolism, The Medical School, The University of Sheffield, Sheffield, United Kingdom;Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China;Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Centre), Tongji University School of Medicine, Shanghai, China;

关键词: articular cartilage;    chondrocyte;    microenvironment;    regenerative medicine;    articular cartilage repair;    osteoarthritis;   

DOI  :  10.3389/fbioe.2021.770655

来源: DOAJ

【 摘 要 】

Articular cartilage is an avascular tissue, with limited ability to repair and self-renew. Defects in articular cartilage can induce debilitating degenerative joint diseases such as osteoarthritis. Currently, clinical treatments have limited ability to repair, for they often result in the formation of mechanically inferior cartilage. In this review, we discuss the factors that affect cartilage homeostasis and function, and describe the emerging regenerative approaches that are informing the future treatment options.

【 授权许可】

Unknown