Near‐Infrared Chemiluminescent Carbon Nanodots and Their Application in Reactive Oxygen Species Bioimaging

Advanced Science

Cheng‐Long Shen¹  Lin Dong¹  Kai‐Kai Liu¹  Chong‐Xin Shan¹  Qing Lou¹  Jin‐Hao Zang¹  Song‐Nan Qu² 

[1] Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Materials Physics Ministry of Education School of Physics and Microelectronics Zhengzhou University Zhengzhou 450052 China;Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials Engineering University of Macau Macau 999078 China;

关键词: bioimaging;    carbon nanodots;    chemiluminescence;    reactive oxygen species;    sensors;    turn‐on probes;   

DOI  :  10.1002/advs.201903525

来源: DOAJ

【 摘 要 】

Abstract Reactive oxygen species (ROS) are generated in the body and related to many pathophysiological processes. Hence, detection of ROS is indispensable in understanding, diagnosis, and treatment of many diseases. Here, near‐infrared (NIR) chemiluminescent (CL) carbon nanodots (CDs) are fabricated for the first time and their CL quantum yield can reach 9.98 × 10−3 einstein mol−1, which is the highest value ever reported for CDs until now. Nanointegration of NIR CDs and peroxalate (P‐CDs) through the bridging effect of amphiphilic triblock copolymer can serve as turn‐on probes for the detection and imaging of hydrogen peroxide (H2O2). Considering high efficiency and large penetration depth of NIR photons, the P‐CDs are employed in bioimaging H2O2 in vitro and in vivo, and the detection limit can reach 5 × 10−9 m, among the best reported of CDs‐based sensors. Moreover, imaging of inflammatory H2O2 in a mouse model of peritonitis is achieved by employing the P‐CDs as sensors. The results may provide a clue for the diagnosis and treatment of inflammation or cancers employing CL CDs as sensors.

【 授权许可】

Unknown