Clinicopathological Characteristics and Prognosis of Signet Ring Gastric Cancer: A Population-Based Study

Frontiers in Oncology

Xing Yuan¹  Qi Xu¹  Lei Chen¹  Qing Wei¹  Jingjing Li¹  Cong Luo¹  Jieer Ying¹  Wei Zhuo²  Zhiyuan Xu³  Changsong Qi⁴  Yiding Gao⁵ 

[1] Department of Abdominal Medical Oncology, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, China;Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China;Department of Gastric Surgery, Institute of Cancer and Basic Medicine (ICBM), Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Chinese Academy of Sciences, Hangzhou, China;Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing, China;The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China;

关键词: carcinoma;    signet ring cell;    nomograms;    stomach neoplasms;    prognosis;   

DOI  :  10.3389/fonc.2021.580545

来源: DOAJ

【 摘 要 】

BackgroundTo better define the clinicopathologic characteristics of signet ring cell (SRC) gastric cancer and build a prognostic model for it.MethodsSRC patient information from 2010 to 2015 were identified using Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier method and log-rank test were used to estimate Overall survival (OS) and to determine associations with histologic subtypes. In COX proportional hazards regression model–based univariate and multivariate analyses, significant variables for construction of a nomogram were screened out. The nomogram was validated by means of the concordance index (CI), calibration plots, and receiver operating characteristics (ROCs) curves.ResultsA total of 11,363 gastric cancer patients were enrolled. On dividing the patients into SRC, well-to-moderately differentiated (WMD) adenocarcinoma, and poorly differentiated (PD) adenocarcinoma, differences among these subgroups emerged. SRC patients were more likely to occur in female and young patients than other histologic subtypes. Larger tumors, stage T4, and node stage N3 were more likely to be found in the SRC group. The survival for SRC patients was better than non-SRC patients in stage I. Univariate and multivariate analyses identified age, tumor site, larger tumor size, advanced T classification, advanced N classification, advanced TNM stage, and surgery of primary site as independent prognostic indicators. Then an OS nomogram was formulated.ConclusionsSRC had distinct clinicopathological characteristics. The nomogram provided an accurate tool to evaluate the prognosis of SRC.

【 授权许可】

Unknown