Identification of an Au(I) N-Heterocyclic Carbene Compound as a Bactericidal Agent Against Pseudomonas aeruginosa

Frontiers in Chemistry

Yanxuan Xie¹  Zong-Wan Mao¹  Wei Xia¹  Jinhui Wang¹  Xiaoshuai Sun²  Xiaojun He²  Taotao Zou³  Yan Long³  Huowen Chen³ 

[1] School of Chemistry, Sun Yat-sen University, Guangzhou, China;School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, China;School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China;

关键词: gram-negative;    Pseudomonas aeruginosa;    antibacterial agents;    Au(I) N-heterocyclic carbene compound;    bactericidal activity;    bacterial resistance;   

DOI  :  10.3389/fchem.2022.895159

来源: DOAJ

【 摘 要 】

The opportunistic pathogen Pseudomonas aeruginosa (P. aeruginosa) causes infections that are difficult to treat, which is due to the bacterial resistance to antibiotics. We herein identify a gold(I) N-heterocyclic carbene compound as a highly potent antibacterial agent towards P. aeruginosa. The compound significantly attenuates P. aeruginosa virulence and leads to low tendency to develop bacterial resistance. The antibacterial mechanism studies show that the compound abrogates bacterial membrane integrity, exhibiting a high bactericidal activity toward P. aeruginosa. The relatively low cytotoxic compound has excellent therapeutic effects on both the eukaryotic cell co-culture and murine wound infection experiments, suggesting its potential application as a bactericidal agent to combat P. aeruginosa infection.

【 授权许可】

Unknown