Nutraceuticals in the Treatment of Pulmonary Arterial Hypertension

International Journal of Molecular Sciences

Roxana Carbó¹  Horacio Osorio-Alonso²  AbrahamS. Arellano-Buendía²  Adrián Hernández-Díazcouder³  Fausto Sánchez-Muñoz⁴  JoséL. Sánchez-Gloria⁴  CarlosA. Guzmán-Martín⁴  Ivan Rubio-Gayosso⁴ 

[1]Departamento de Biomedicina Cardiovascular, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico

[2]Departamento de Fisiopatología Cardio-Renal, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico

[3]Departamento de Inmunología, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico

[4]Sección de Estudios de Posgrado, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico

关键词: pulmonary arterial hypertension;    nutraceuticals;    antihypertensive;    antioxidant;    antiproliferative;    anti-inflammatory;   

DOI  :  10.3390/ijms21144827

来源: DOAJ

【 摘 要 】

Pulmonary arterial hypertension (PAH) is a severe disease characterized by the loss and obstructive remodeling of the pulmonary arterial wall, causing a rise in pulmonary arterial pressure and pulmonary vascular resistance, which is responsible for right heart failure, functional decline, and death. Although many drugs are available for the treatment of this condition, it continues to be life-threatening, and its long-term treatment is expensive. On the other hand, many natural compounds present in food have beneficial effects on several cardiovascular conditions. Several studies have explored many of the potential beneficial effects of natural plant products on PAH. However, the mechanisms by which natural products, such as nutraceuticals, exert protective and therapeutic effects on PAH are not fully understood. In this review, we analyze the current knowledge on nutraceuticals and their potential use in the protection and treatment of PAH, as well as whether nutraceuticals could enhance the effects of drugs used in PAH through similar mechanisms.

【 授权许可】

Unknown