Recent Progress in Lyme Disease and Remaining Challenges

Frontiers in Medicine

Aydogan Ozcan¹  Felicia Keesing²  Kim Lewis³  Choukri Ben Mamoun⁴  Ricardo Maggi⁵  Edward B. Breitschwerdt⁵  Frank Yang⁶  Bennett Nemser⁷  Dino Di Carlo⁸  Omai Garner⁸  Zachary Ballard⁸  Albert Garcia-Romeu⁸  Hyou-Arm Joung⁸  Nicole Baumgarth⁹  Roland R. Griffiths⁹  Brian A. Fallon^1,10  Richard S. Ostfeld^1,11  Mecaila E. McClune^1,12  Brandon L. Jutras^1,12  Richard T. Marconi^1,13  John Aucott^1,14  Mark J. Soloski^1,14  Alison W. Rebman^1,14  Allison Bailey^1,15  Avi Ma'ayan^1,15  Jason R. Bobe^1,15  Panga Jaipal Reddy^1,16  Robert L. Moritz^1,16  Elizabeth J. Horn^1,17  Ying Zhang^1,18  Monica E. Embers^1,19 

[1] Alexandra Cohen Foundation, Stamford, CT, United States;0Bard College, Annandale, NY, United States;1Department of Biology, Northeastern University, Boston, MA, United States;2Yale University School of Medicine, New Haven, CT, United States;3Department of Clinical Sciences, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States;4Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, United States;;5Steven &6University of California, Los Angeles, Los Angeles, CA, United States;7Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States;;8Center for Immunology and Infectious Diseases and the Department of Pathology, Microbiology &Cary Institute of Ecosystem Studies, Millbrook, NY, United States;Department of Biochemistry, Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA, United States;Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA, United States;Division of Rheumatology, Department of Medicine, Lyme Disease Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States;Icahn School of Medicine at Mount Sinai, New York, NY, United States;Institute for Systems Biology, Seattle, WA, United States;Lyme Disease Biobank, Portland, OR, United States;State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;Tulane University Health Sciences, New Orleans, LA, United States;

关键词: Lyme disease;    pathogenesis;    diagnosis;    treatment;    prevention;    field building;   

DOI  :  10.3389/fmed.2021.666554

来源: DOAJ

【 摘 要 】

Lyme disease (also known as Lyme borreliosis) is the most common vector-borne disease in the United States with an estimated 476,000 cases per year. While historically, the long-term impact of Lyme disease on patients has been controversial, mounting evidence supports the idea that a substantial number of patients experience persistent symptoms following treatment. The research community has largely lacked the necessary funding to properly advance the scientific and clinical understanding of the disease, or to develop and evaluate innovative approaches for prevention, diagnosis, and treatment. Given the many outstanding questions raised into the diagnosis, clinical presentation and treatment of Lyme disease, and the underlying molecular mechanisms that trigger persistent disease, there is an urgent need for more support. This review article summarizes progress over the past 5 years in our understanding of Lyme and tick-borne diseases in the United States and highlights remaining challenges.

【 授权许可】

Unknown