An update on immunopathogenesis, diagnosis, and treatment of multiple sclerosis

Brain and Behavior

Neeta Garg¹ 

[1] Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts

关键词: Demyelination;    diagnosis;    etiology;    immunomodulator;    multiple sclerosis;    pathogenesis;    treatment;   

DOI  :  10.1002/brb3.362

来源: Wiley

【 摘 要 】

Abstract

Background

Multiple sclerosis is an acquired demyelinating disease of the central nervous system. It is the second most common cause of disability in adults in United States after head trauma.

Discussion

The etiology of MS is probably multifactorial, related to genetic, environmental, and several other factors. The pathogenesis is not fully understood but is believed to involve T-cell-mediated inflammation directed against myelin and other related proteins with a possible role for B cells. The McDonald criteria have been proposed and revised over the years to guide the diagnosis of MS and are based on clinical presentation and magnetic resonance imaging (MRI) of the brain and spinal cord to establish dissemination in time and space. The treatment of MS includes disease modification with immunomodulator drugs and symptom management to address the specific symptoms such as fatigue, spasticity, and pain.

Conclusion

An update on etiology, pathogenesis, diagnosis, and immunomodulatory treatment of MS is presented.

【 授权许可】

CC BY   
© 2015 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.