The development of large-scale de-identified biomedical databases in the age of genomics—principles and challenges

Human Genomics

Fida K. Dankar¹  Samar K. Dankar²  Andrey Ptitsyn³ 

[1] College of IT, UAEU;Faculty of Sciences, University of Balamand;Gloucester Marine Genomics Institute;

关键词: Biomedical database;    Data privacy;    Data governance;    Whole genome sequencing;   

DOI  :  10.1186/s40246-018-0147-5

来源: DOAJ

【 摘 要 】

Abstract Contemporary biomedical databases include a wide range of information types from various observational and instrumental sources. Among the most important features that unite biomedical databases across the field are high volume of information and high potential to cause damage through data corruption, loss of performance, and loss of patient privacy. Thus, issues of data governance and privacy protection are essential for the construction of data depositories for biomedical research and healthcare. In this paper, we discuss various challenges of data governance in the context of population genome projects. The various challenges along with best practices and current research efforts are discussed through the steps of data collection, storage, sharing, analysis, and knowledge dissemination.

【 授权许可】

Unknown