期刊论文详细信息
Journal of Translational Medicine
From biobank and data silos into a data commons: convergence to support translational medicine
Anna Tinker1  Rebecca Asiimwe2  David G. Huntsman3  Samuel Leung4  Rachel Wan5  Shanzhao Wang6  Stephanie Lam7  Jessica N. McAlpine7  Michelle M. M. Woo7  Aline Talhouk8 
[1] Department of Medicine, Faculty of Medicine, Division of Medical Oncology, University of British Columbia, 2775 Laurel Street, V5Z 1M9, Vancouver, BC, Canada;BC Cancer, 600 West 10th Avenue, V5Z 4E6, Vancouver CentreVancouver, BC, Canada;OVCARE Research Program, Vancouver, Canada;Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, V5Z 1L3, Vancouver, BC, Canada;BC Children’s Hospital Research Institute, 938 West 28th Avenue, V5Z 4H4, Vancouver, BC, Canada;Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, V5Z 1L3, Vancouver, BC, Canada;Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, 2211 Wesbrook Mall, V6T 2B5, Vancouver, BC, Canada;Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada;OVCARE Research Program, Vancouver, Canada;Department of Molecular Oncology, BC Cancer Research Centre, 675 West 10th Avenue, V5Z 1L3, Vancouver, BC, Canada;Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, 2211 Wesbrook Mall, V6T 2B5, Vancouver, BC, Canada;OVCARE Research Program, Vancouver, Canada;Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, 2211 Wesbrook Mall, V6T 2B5, Vancouver, BC, Canada;BC Cancer, 600 West 10th Avenue, V5Z 4E6, Vancouver CentreVancouver, BC, Canada;Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, 2211 Wesbrook Mall, V6T 2B5, Vancouver, BC, Canada;OVCARE Research Program, Vancouver, Canada;Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada;OVCARE Research Program, Vancouver, Canada;OVCARE Research Program, Vancouver, Canada;Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of British Columbia, 5th Floor (593), 828 West 10th Ave, V5Z 1M9, Vancouver, BC, Canada;
关键词: Biobanks;    Biospecimens;    Biobank-technologies;    Precision medicine;    Data commons;    Laboratory Information Management Systems (LIMS);    Federated systems;    Data governance;   
DOI  :  10.1186/s12967-021-03147-z
来源: Springer
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【 摘 要 】

BackgroundTo drive translational medicine, modern day biobanks need to integrate with other sources of data (clinical, genomics) to support novel data-intensive research. Currently, vast amounts of research and clinical data remain in silos, held and managed by individual researchers, operating under different standards and governance structures; a framework that impedes sharing and effective use of data. In this article, we describe the journey of British Columbia’s Gynecological Cancer Research Program (OVCARE) in moving a traditional tumour biobank, outcomes unit, and a collection of data silos, into an integrated data commons to support data standardization and resource sharing under collaborative governance, as a means of providing the gynecologic cancer research community in British Columbia access to tissue samples and associated clinical and molecular data from thousands of patients.ResultsThrough several engagements with stakeholders from various research institutions within our research community, we identified priorities and assessed infrastructure needs required to optimize and support data collections, storage and sharing, under three main research domains: (1) biospecimen collections, (2) molecular and genomics data, and (3) clinical data. We further built a governance model and a resource portal to implement protocols and standard operating procedures for seamless collections, management and governance of interoperable data, making genomic, and clinical data available to the broader research community.ConclusionsProper infrastructures for data collection, sharing and governance is a translational research imperative. We have consolidated our data holdings into a data commons, along with standardized operating procedures to meet research and ethics requirements of the gynecologic cancer community in British Columbia. The developed infrastructure brings together, diverse data, computing frameworks, as well as tools and applications for managing, analyzing, and sharing data. Our data commons bridges data access gaps and barriers to precision medicine and approaches for diagnostics, treatment and prevention of gynecological cancers, by providing access to large datasets required for data-intensive science.

【 授权许可】

CC BY   

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