The curse of angiopoietin-2 in ARDS: on stranger TI(E)des

Critical Care

Philipp Kümpers¹  Alexander Lukasz¹ 

[1] Department of Medicine D, Division of General Internal Medicine, Nephrology, and Rheumatology, University Hospital Münster;

关键词: Permeability;    Lung;    Pneumonia;    ARDS;    Endothelium;    Angiopoietin-2;   

DOI  :  10.1186/s13054-018-1978-0

来源: DOAJ

【 摘 要 】

Abstract Pulmonary inflammation and vascular leakage are hallmarks of acute respiratory distress syndrome (ARDS), a life-threatening condition, for which there is no specific pharmacologic treatment. Recent literature suggests that leaky vessels in pulmonary infection and ARDS may be mediated through dysregulation of a non-redundant endothelial control pathway, the Tie2 receptor and its ligands, the angiopoietins. This Viewpoint summarizes results from cell-based experiments, animal models and clinical studies underlining the potential of Tie2 targeted interventions in reducing infection-mediated pulmonary hyperpermeability.

【 授权许可】

Unknown