Recent Advancements in the Medical Treatment of Diabetic Retinal Disease

International Journal of Molecular Sciences

Maja Szymanska¹  Timothy E. Yap¹  Maria F. Cordeiro¹  Daanyaal Mahmood¹ 

[1] The Imperial College Ophthalmic Research Group (ICORG), Imperial College London, London NW1 5QH, UK;

关键词: diabetic retinopathy;    diabetic macular edema;    angiogenesis;    inflammation;    glycemic control;    pancreatic transplantation;   

DOI  :  10.3390/ijms22179441

来源: DOAJ

【 摘 要 】

Diabetic retinal disease remains one of the most common complications of diabetes mellitus (DM) and a leading cause of preventable blindness. The mainstay of management involves glycemic control, intravitreal, and laser therapy. However, intravitreal therapy commonly requires frequent hospital visits and some patients fail to achieve a significant improvement in vision. Novel and long-acting therapies targeting a range of pathways are warranted, while evidence to support optimal combinations of treatments is currently insufficient. Improved understanding of the molecular pathways involved in pathogenesis is driving the development of therapeutic agents not only targeting visible microvascular disease and metabolic derangements, but also inflammation and accelerated retinal neurodegeneration. This review summarizes the current and emerging treatments of diabetic retinal diseases and provides an insight into the future of managing this important condition.

【 授权许可】

Unknown