Pilot Study to Characterize Middle Cerebral Artery Dynamic Response to an Acute Bout of Moderate Intensity Exercise at 3‐ and 6‐Months Poststroke

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Luke Ledbetter¹  Michael G. Abraham²  Stephen X. Bai³  Sarah M. Eickmeyer³  Alicen A. Whitaker⁴  Sophy J. Perdomo⁴  Sandra A. Billinger⁴  Jaimie L. Ward⁴  Allegra Morton⁴  Carolyn S. Kaufman⁴ 

[1] Department of Diagnostic Radiology University of Kansas Medical Center Kansas City KS;Department of Neurology University of Kansas Medical Center Kansas City KS;Department of Physical Medicine and Rehabilitation University of Kansas Medical Center Kansas City KS;Department of Physical Therapy and Rehabilitation Science University of Kansas Medical Center Kansas City KS;

关键词: blood flow;    brain;    exercise;    stroke;    vascular function;   

DOI  :  10.1161/JAHA.120.017821

来源: DOAJ

【 摘 要 】

Background The primary aim of this study was to characterize the middle cerebral artery blood velocity (MCAv) dynamic response to an acute bout of exercise in humans at 3‐ and 6‐months poststroke. As a secondary objective, we grouped individuals according to the MCAv dynamic response to the exercise bout as responder or nonresponder. We tested whether physical activity, aerobic fitness, and exercise mean arterial blood pressure differed between groups. Methods and Results Transcranial Doppler ultrasound measured MCAv during a 90‐second baseline followed by a 6‐minute moderate intensity exercise bout. Heart rate, mean arterial blood pressure, and end‐tidal CO2 were additional variables of interest. The MCAv dynamic response variables included the following: baseline, time delay, amplitude, and time constant. Linear mixed model revealed no significant differences in our selected outcomes between 3‐ and 6‐months poststroke. Individuals characterized as responders demonstrated a faster time delay, higher amplitude, and reported higher levels of physical activity and aerobic fitness when compared with the nonresponders. No between‐group differences were identified for baseline, time constant, or exercise mean arterial blood pressure. In the nonresponders, we observed an immediate rise in MCAv following exercise onset followed by an immediate decline to near baseline values, while the responders showed an exponential rise until steady state was reached. Conclusions The MCAv dynamic response profile has the potential to provide valuable information during an acute exercise bout following stroke. Individuals with a greater MCAv response to the exercise stimulus reported statin use and regular participation in exercise.

【 授权许可】

Unknown