Vaccination With Sporozoites: Models and Correlates of Protection

Frontiers in Immunology

Laurent Rénia¹  Daniel McGuire²  Yun Shan Goh³ 

[1] Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;School of Biological Sciences, Nanyang Technological University, Singapore, Singapore;Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore, Singapore;

关键词: Plasmodium falciparum;    malaria;    sporozoites;    protection;    vaccine;    models;   

DOI  :  10.3389/fimmu.2019.01227

来源: DOAJ

【 摘 要 】

Despite continuous efforts, the century-old goal of eradicating malaria still remains. Multiple control interventions need to be in place simultaneously to achieve this goal. In addition to effective control measures, drug therapies and insecticides, vaccines are critical to reduce mortality and morbidity. Hence, there are numerous studies investigating various malaria vaccine candidates. Most of the malaria vaccine candidates are subunit vaccines. However, they have shown limited efficacy in Phase II and III studies. To date, only whole parasite formulations have been shown to induce sterile immunity in human. In this article, we review and discuss the recent developments in vaccination with sporozoites and the mechanisms of protection involved.

【 授权许可】

Unknown