Associations between comorbidities and annual incidence plus frequency of asthma exacerbation hospitalisation during the past year: data from CARN study

BMC Pulmonary Medicine

Wenqiao Wang¹  Jiangtao Lin¹  Dejun Sun²  Xiaohong Yang³  Mao Huang⁴  Lan Yang⁵  Jie Zhang⁶  Wei Zhou⁷  Xianwei Ye⁸  Yijiang Huang⁹  Zhuochang Chen^1,10  Luming Dai^1,11  Shaoxi Cai^1,12  Huaping Tang^1,13  Yuhai Gu^1,14  Xin Zhou^1,15  Jianying Xu^1,16  Rongyu Liu^1,17  Qichang Lin^1,18  Yiqiang Chen^1,19  Jianmin Huo^2,20  Xiaoju Liu^2,21  Wei Zhang^2,22  Jianying Zhou^2,23  Yadong Yuan^2,24  Ping Jiang^2,25  Huiguo Liu^2,26  Chengping Hu^2,27  Changzheng Wang^2,28  Ping Chen^2,29  Chuntao Liu^3,30 

[1] Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital;Department of Pulmonary and Critical Care Medicine, Inner Mongolia People’s Hospital;Department of Pulmonary and Critical Care Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region;Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University;Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Xi’an Jiaotong University;Department of Pulmonary and Critical Care Medicine, The Second Hospital of Jilin University;Department of Respiration, General Hospital of Ningxia Medical University;Department of Respiration, Guizhou Provincial People’s Hospital;Department of Respiration, Hainan General Hospital;Department of Respiration, Henan Provincial People’s Hospital;Department of Respiration, Kunming General Hospital of the People’s Liberation Army;Department of Respiration, Nanfang Hospital;Department of Respiration, Qingdao Municipal Hospital;Department of Respiration, Qinghai People’s Hospital;Department of Respiration, Shanghai Central Hospital;Department of Respiration, Shanxi Bethune Hospital;Department of Respiration, The First Affiliated Hospital of Anhui Medical University;Department of Respiration, The First Affiliated Hospital of Fujian Medical University;Department of Respiration, The First Affiliated Hospital of Guangxi Medical University;Department of Respiration, The First Affiliated Hospital of Harbin Medical University;Department of Respiration, The First Affiliated Hospital of Lanzhou University;Department of Respiration, The First Affiliated Hospital of Nanchang University;Department of Respiration, The First Affiliated Hospital of Zhejiang University School of Medicine;Department of Respiration, The Second Hospital of Hebei Medical University;Department of Respiration, Tianjin First Central Hospital;Department of Respiration, Tongji Hospital;Department of Respiration, Xiangya Hospital;Department of Respiration, Xinqiao Hospital, Third Military Medical University;Department of Respiratory Diseases, General Hospital of Shenyang Military Command;Department of Respiratory and Critical Care Medicine, West China School of Medicine and West China Hospital, Sichuan University;

关键词: Asthma;    Exacerbation;    Hospitalisation;    Comorbidity;    Multi-centre cross-sectional study;   

DOI  :  10.1186/s12890-022-02038-3

来源: DOAJ

【 摘 要 】

Abstract Purpose While asthma comorbidities are associated with higher health care utilisation, lower quality of life and poorer asthma control, the impact of asthma comorbidities on hospitalisation for asthma exacerbation (H-AX) remains less recognised. We aim to analyse the impact of asthma comorbidities on H-AX. Methods Based on a national survey on asthma control and disease perception (CARN 2015 study), we analysed the impact of comorbidities on annual incidence and frequency of H-AX in China. Information on demographic characteristics, asthma comorbidities and annual incidence and frequency of H-AX were presented in this study. Results Among 3875 ambulatory asthma patients, 75.9% (2941/3875) had comorbidities, and 26.4% (1017/3858) experienced H-AX during past year. After adjusting for confounding factors such as demographic data, smoking status and asthma control, COPD [OR = 2.189, 95% CI (1.673, 2.863)] and coronary heart disease [OR = 1.387, 95% CI (1.032, 1.864)] were associated with higher annual incidence, while allergic rhinitis [OR = 0.692, 95% CI (0.588, 0.815)] was associated with lower annual incidence, of H-AX. In terms of frequency, allergic rhinitis [OR = 1.630, 95% CI (1.214, 2.187)], COPD [OR = 1.472, 95% CI (1.021, 2.122)] and anxiety [OR = 2.609, 95% CI (1.051, 6.477)] showed statistically significant correlation with frequent H-AX. Conclusions COPD and coronary heart disease were associated with higher annual incidence, while allergic rhinitis was associated with lower annual incidence of H-AX. Allergic rhinitis, COPD and anxiety were associated with frequent H-AX. Comorbidities may have an important role in the risk and frequency of annual hospitalisations due to asthma exacerbation. The goal of asthma control should rely on a multi-disciplinary treatment protocol.

【 授权许可】

Unknown