Phytosterol plasma concentrations and coronary heart disease in the prospective Spanish EPIC cohort

Journal of Lipid Research

Emilio Ros¹  Carmen Navarro²  Montserrat Cofán³  Nerea Larrañaga³  Carlos A. González⁴  Dolores Corella⁵  Laudina Rodríguez⁵  Concepción Moreno-Iribas⁶  Verónica Escurriol⁶  Carmen Martínez⁷ 

[1] Andalusian School of Public Health, Granada, Spain;CIBER Epidemiología y Salud Pública, Instituto de Salud Carlos III, Spain;CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Spain;Public Health Department of Gipuzkoa, Gipuzkoa, Spain;CIBER Epidemiología y Salud Pública, Instituto de Salud Carlos III, Spain;Lipid Clinic, Endocrinology and Nutrition Service, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, Barcelona, Spain;Public Health Institute of Navarra, Pamplona, Spain;

关键词: plant sterols;    sitosterol;    campesterol;    lathosterol;    cholesterol;    European Prospective Investigation into Cancer and Nutrition;   

DOI  :  

来源: DOAJ

【 摘 要 】

Phytosterol intake with natural foods, a measure of healthy dietary choices, increases plasma levels, but increased plasma phytosterols are believed to be a coronary heart disease (CHD) risk factor. To address this paradox, we evaluated baseline risk factors, phytosterol intake, and plasma noncholesterol sterol levels in participants of a case control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) Spanish cohort who developed CHD (n = 299) and matched controls (n = 584) who remained free of CHD after a 10 year follow-up. Sitosterol-to-cholesterol ratios increased across tertiles of phytosterol intake (P = 0.026). HDL-cholesterol level increased, and adiposity measures, cholesterol/HDL ratios, and levels of glucose, triglycerides, and lathosterol, a cholesterol synthesis marker, decreased across plasma sitosterol tertiles (P < 0.02; all). Compared with controls, cases had nonsignificantly lower median levels of phytosterol intake and plasma sitosterol. The multivariable-adjusted odds ratio for CHD across the lowest to highest plasma sitosterol tertile was 0.59 (95% confidence interval, 0.36–0.97). Associations were weaker for plasma campesterol. The apolipoprotein E genotype was unrelated to CHD risk or plasma phytosterols. The data suggest that plasma sitosterol levels are associated with a lower CHD risk while being markers of a lower cardiometabolic risk in the EPIC-Spain cohort, a population with a high phytosterol intake.

【 授权许可】

Unknown