Comparison of the effects of maximal dose atorvastatin and rosuvastatin therapy on cholesterol synthesis and absorption markers*[S]

Journal of Lipid Research

卷:50

Peter H. Jones¹  Nirupa R. Matthan¹  Nancy A. Resteghini²  Ernst J. Schaefer²  Masumi Ai³  Seiko Otokozawa⁴  Evan A. Stein⁵  Thomas M. van Himbergen⁵ 

[1] Cardiovascular Nutrition Laboratory, Human Nutrition Research Center on Aging at Tufts University, Boston, MA;

[2] Cardiovascular Research Laboratory, Friedman School of Nutrition Science and Policy at Tufts University and Tufts University School of Medicine, Boston, MA;

[3] Department of Medicine, Baylor College of Medicine, Houston, TX;

[4] Metabolic and Atherosclerosis Research Center, Cincinnati, OH;

[5] Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging at Tufts University, Boston, MA;

关键词: plasma sterols;    lathosterol;    campesterol;    sitosterol;    STELLAR study;   

DOI  :  

来源: DOAJ

【 摘 要 】

We measured plasma markers of cholesterol synthesis (lathosterol) and absorption (campesterol, sitosterol, and cholestanol) in order to compare the effects of maximal doses of rosuvastatin with atorvastatin and investigate the basis for the significant individual variation in lipid lowering response to statin therapy. Measurements were performed in participants (n = 135) at baseline and after 6 weeks on either rosuvastatin (40 mg/day) or atorvastatin (80 mg/day) therapy. Plasma sterols were measured using gas-liquid chromatography. Rosuvastatin and atorvastatin significantly (P < 0.001) altered plasma total cholesterol (C) levels by −40%, and the ratios of lathosterol/C by −64% and −68%, and campesterol/C by +52% and +72%, respectively, with significant differences (P < 0.001) between the treatment groups for the latter parameter. When using absolute values of these markers, subjects with the greatest reductions in both synthesis (lathosterol) and absorption (campesterol) had significantly greater reductions in total C than subjects in whom the converse was true (−46% versus −34%, P = 0.001), with similar effects for LDL-C. Rosuvastatin and atorvastatin decreased markers of cholesterol synthesis and increased markers of fractional cholesterol absorption, with rosuvastatin having significantly less effect on the latter parameter than atorvastatin. In addition, alterations in absolute values of plasma sterols correlated with the cholesterol lowering response.

【 授权许可】

Unknown