Mental Health in Persons With Chronic Myeloid Leukemia During the SARS-CoV-2 Pandemic: The Need for Increased Access to Health Care Services

Frontiers in Psychiatry

Li Meng¹  Weiming Li²  Tao Wang³  Yanli Zhang⁴  Xiaoli Liu⁵  Huanling Zhu⁶  Rong Liang⁷  Robert Peter Gale⁸  Dayu Shi⁹  Mei Bao⁹  Qian Jiang⁹  Zongru Li⁹  Xuelin Dou⁹  Sen Yang⁹  Li Zhou^1,10  Bingcheng Liu^1,11 

[1] 0Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;1Department of Hematology, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China;Department of Epidemiology and Biostatistics School of Public Health Peking University Health Science Center, Beijing, China;Department of Hematology, Henan Provincial Tumor Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China;Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China;Department of Hematology, West China Hospital, Sichuan University, Chengdu, China;Department of Hematology, Xijing Hospital, Air Force Medical University, Xi'an, China;Hematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, United Kingdom;Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, China;Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China;State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology, Chinese Academy of Medical Sciences, Tianjin, China;

关键词: SARS-CoV-2;    chronic myeloid leukemia;    mental health;    depression;    anxiety;    distress;   

DOI  :  10.3389/fpsyt.2021.679932

来源: DOAJ

【 摘 要 】

Mental health problems in the general population have been reported during the SARS-CoV-2 pandemic; however, there were rare data in persons with chronic myeloid leukemia (CML). Therefore, we performed a cross-sectional study on mental health evaluated using the 9-item Patient Health Questionnaire (PHQ-9; depression), the 7-item Generalized Anxiety Disorder (GAD-7; anxiety), and the 22-item Impact of Event Scale—Revised (IES-R; distress), including subscales of avoidance, intrusion, and hyper-arousal in persons with CML, non-cancer persons, and immediate family members of persons with cancer as controls (≥16 years) by an online survey. Data from 3,197 persons with CML and 7,256 controls were collected. In multivariate analyses, CML was significantly associated with moderate to severe depression (OR = 1.6; 95% Confidence Interval [CI], 1.4, 1.9; p < 0.001), anxiety (OR = 1.4 [1.1, 1.7]; p = 0.001), distress (OR = 1.3 [1.1, 1.5]; p < 0.001), and hyper-arousal (OR = 1.5 [1.3, 1.6]; p < 0.001). Moreover, delay in regular monitoring was significantly associated with depression (OR 1.3 [1.0, 1.7]; p = 0.024), anxiety (OR = 1.3 [1.0, 1.8]; p = 0.044), avoidance (OR = 1.2 [1.0, 1.4]; p = 0.017), and intrusion (OR = 1.2 [1.0, 1.4]; p = 0.057); tyrosine kinase-inhibitor dose reduction or discontinuation, depression (OR = 1.9 [1.3, 2.8]; p = 0.001), distress (OR = 2.0 [1.4, 2.8]; p < 0.001), avoidance (OR = 1.6 [1.2, 2.1]; p = 0.004), intrusion (OR = 1.6 [1.1, 2.1]; p = 0.006), and hyper-arousal (OR = 1.3 [1.0, 1.8]; p = 0.088). We concluded that persons with CML during the SARS-CoV-2 pandemic have worse mental health including depression, anxiety, and distress symptoms. Decreasing or stopping monitoring or dose resulted in adverse mental health consequences.

【 授权许可】

Unknown