Deeping in the Role of the MAP-Kinases Interacting Kinases (MNKs) in Cancer

International Journal of Molecular Sciences

Raquel Ferreras-Martín¹  VíctorM. González¹  Celia Pinto-Díez¹  MaríaElena Martín¹  Rebeca Carrión-Marchante¹ 

[1] Grupo de Aptámeros, Servicio de Bioquímica-Investigación, IRYCIS-Hospital Ramón y Cajal, Madrid, Ctra. Colmenar Km. 9100, 28034 Madrid, Spain;

关键词: antitumor drug;    cancer;    eIF4E;    metastasis;    MNK;    therapy;   

DOI  :  10.3390/ijms21082967

来源: DOAJ

【 摘 要 】

The mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs) are involved in oncogenic transformation and can promote metastasis and tumor progression. In human cells, there are four MNKs isoforms (MNK1a/b and MNK2a/b), derived from two genes by alternative splicing. These kinases play an important role controlling the expression of specific proteins involved in cell cycle, cell survival and cell motility via eukaryotic initiation factor 4E (eIF4E) regulation, but also through other substrates such as heterogeneous nuclear ribonucleoprotein A1, polypyrimidine tract-binding protein-associated splicing factor and Sprouty 2. In this review, we provide an overview of the role of MNK in human cancers, describing the studies conducted to date to elucidate the mechanism involved in the action of MNKs, as well as the development of MNK inhibitors in different hematological cancers and solid tumors.

【 授权许可】

Unknown