eIF4E as a Control Target for Viruses

Viruses

Hilda Montero¹  Rebeca Garc໚-Román¹  Silvia I. Mora² 

[1] Public Health Institute, University of Veracruz, Veracruz 91190, Mexico; E-Mail:;Preparative Procedures and Access to Proteomic Services Unit, Institute of Biomedical Research, National Autonomous University of Mexico. Distrito Federal 04510, Mexico; E-Mail:

关键词: eIF4E;    4EBP;    virus;    translation;    latency;    cancer;   

DOI  :  10.3390/v7020739

来源: mdpi

【 摘 要 】

Translation is a complex process involving diverse cellular proteins, including the translation initiation factor eIF4E, which has been shown to be a protein that is a point for translational regulation. Viruses require components from the host cell to complete their replication cycles. Various studies show how eIF4E and its regulatory cellular proteins are manipulated during viral infections. Interestingly, viral action mechanisms in eIF4E are diverse and have an impact not only on viral protein synthesis, but also on other aspects that are important for the replication cycle, such as the proliferation of infected cells and stimulation of viral reactivation. This review shows how some viruses use eIF4E and its regulatory proteins for their own benefit in order to spread themselves.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.