Safety and immunogenicity of inactivated SARS-CoV-2 vaccines in people living with HIV

Emerging Microbes and Infections

Hong Ren¹  Gaoli Zhang¹  Dachuan Cai¹  Ting Lu¹  Xiaofeng Shi¹  Dazhi Zhang¹  Zhiwei Chen¹  Pan Xu¹  Ling Ao¹  Yuting Wang¹  Peng Hu¹  Mingli Peng¹  Min Chen¹  Dejuan Xiang¹  Xingqian Ren²  Zisheng Li²  Yu Cao² 

[1] Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China;The People’s Hospital of Tongliang District, Chongqing, People’s Republic of China;

关键词: SARS-CoV-2 vaccine;    COVID-19;    PLWH;    safety;    humoral immune response;   

DOI  :  10.1080/22221751.2022.2059401

来源: DOAJ

【 摘 要 】

It is important to know the safety and efficacy of vaccination in immunocompromised people living with HIV (PLWH), but currently, there is limited data on the inactivated SARS-CoV-2 vaccines’ safety and immune responses in PLWH. In this prospective observational study, 139 PLWH and 120 healthy controls were enrolled and monitored for 21–105 days after a two-dose vaccination. The safety, anti-receptor binding domain IgG (anti-RBD-IgG) and anti-spike-IgG responses, and RBD-specific memory B cell (MBC) responses were evaluated. The overall adverse events within seven days were reported in 12.9% (18/139) of PLWH and 13.3% (16/120) of healthy controls. No serious adverse events occurred in both groups. Overall, the seroprevalence of anti-RBD-IgG in PLWH was significantly decreased (87.1% vs. 99.2%; p<0.001). The geometric mean end-point titer (GMT) of anti-RBD-IgG in PLWH was also reduced, especially in patients with CD4 counts <200 cells/µL, regardless of age, gender, or HIV viral load. GMTs of anti-RBD-IgG in both PLWH and healthy controls declined gradually over time. Similar results were also observed in the anti-spike-IgG response. The frequency of RBD-specific MBCs in PLWH decreased (p<0.05), and then remained stable over time. Lastly, through multivariate analysis, we found the factors that predicted a less robust response to inactivated vaccines in PLWH were a low CD4 count and long time interval after vaccination. In conclusion, inactivated vaccines are well-tolerated in PLWH but with low immunogenicity. Therefore, SARS-CoV-2 vaccines and booster doses should be given priority in PLWH, especially in patients with low CD4 counts.Trial registration: ClinicalTrials.gov identifier: NCT05043129..

【 授权许可】

Unknown