Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury

Neural Regeneration Research

关键词: nerve regeneration;    neuroprotection;    traumatic brain injury;    cold-induced brain injury;    enoxaparin;    anti-oxidative;    apoptosis;    neural regeneration;   

DOI  :  10.4103/1673-5374.206646

来源: DOAJ

【 摘 要 】

Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after modeling, male BALB/c mouse models of cold-induced traumatic brain injury were intraperitoneally administered 3 and 10 mg/kg enoxaparin or isotonic saline solution. Twenty-four hours later, enoxaparin at 10 mg/kg greatly reduced infarct volume, decreased cell apoptosis in the cortex and obviously increased serum level of total antioxidant status. By contrast, administration of enoxaparin at 3 mg/kg did not lead to these changes. These findings suggest that enoxaparin exhibits neuroprotective effect on cold-induced traumatic brain injury in a dose-dependent manner.

【 授权许可】

Unknown