SARS-CoV-2 in Kidney Transplant Patients: A Real-Life Experience

Frontiers in Medicine

Reynaud Laura¹  Gallicchio Antonella¹  Zotta Irene¹  Salemi Fabrizio¹  Viceconte Giulio¹  Schiano Moriello Nicola¹  Stagnaro Francesca¹  “Federico II” COVID-19 Team¹  Cattaneo Letizia¹  Minervini Fulvio¹  Scordino Fabrizio¹  Zappulo Emanuela¹  Di Filippo Giovanni¹  Sardanelli Alessia¹  Tosone Grazia¹  Gentile Ivan¹  Foggia Maria¹  Mercinelli Simona¹  Buonomo Antonio Riccardo¹  Giaccone Agnese¹  Borrelli Francesco¹  Lanzardo Amedeo¹  Pinchera Biagio¹  Conte MariaCarmela Domenica¹  Amicone Maria¹  Cotugno Mariarosaria¹  Piccione Amerigo¹  Scotto Riccardo¹  Riccardo Scotto²  Biagio Pinchera²  Antonio Riccardo Buonomo²  Ivan Gentile²  Maria Foggia²  Giuseppe Celentano³  Lorenzo Spirito³  Roberto La Rocca³  Lucia Ferreri⁴  Rosa Carrano⁴  Stefano Federico⁴ 

[1] ;Department of Clinical Medicine and Surgery, University of Naples “Federico II”, Naples, Italy;Department of Neurosciences, Reproductive and Odontostomatological Sciences, Section of Urology, University of Naples “Federico II”, Naples, Italy;Department of Public Health, University of Naples “Federico II”, Naples, Italy;

关键词: kidney transplant;    SARS-CoV-2;    COVID-19;    transplant;    immunosuppression;   

DOI  :  10.3389/fmed.2022.864865

来源: DOAJ

【 摘 要 】

BackgroundThe COVID-19 pandemic has significantly impacted the management of solid organ transplant recipients and on clinical evolution in post-transplantation. Little is known on the impact of SARS-CoV-2 infection in these patients. The severity and lethality of this disease in solid organ transplant patients are higher thanin the general population. This study aims to describe clinical characteristics of SARS-CoV-2 infection in solid organ transplant recipients followed in our center.MethodsIn this observational study, we enrolled all kidney transplant recipientsattending the A.O.U. Federico II of Naples from March 2020 to January 2021. For each patient we evaluated the epidemiological and clinical characteristics as well as outcome.ResultsWe enrolled 369 kidney transplant patients (229, male, 62%). Of these, 51 (13.8%) acquired SARS-CoV-2 infection and 29 showed symptomatic disease. Of the 51 patients with the infection, 48 (94.11%) had at least one comorbidity and such comorbidities did not constitute a risk factor for a more severe disease. Hospitalization was necessary for 7 (13.7%) patients. Of these, 2 required low-flow oxygen supplementation, 3 non-invasive/high flow ventilation and 2 invasive ventilation. Finally, 2 patients died.ConclusionsOur study shows a lower mortality and hospitalization rate compared to figures available in the literature (4% vs. 13–30% and 14% vs. 32–100%, respectively). Furthermore, the comorbidities examined (hypertension, dyslipidemia, and diabetes) did not constitute a risk factor for a more severe disease condition in this patient category. Further studies with larger sample size are necessary to confirm these data.

【 授权许可】

Unknown