期刊论文详细信息
Frontiers in Medicine
SARS-CoV-2 in Kidney Transplant Patients: A Real-Life Experience
Reynaud Laura1  Gallicchio Antonella1  Zotta Irene1  Salemi Fabrizio1  Viceconte Giulio1  Schiano Moriello Nicola1  Stagnaro Francesca1  “Federico II” COVID-19 Team1  Cattaneo Letizia1  Minervini Fulvio1  Scordino Fabrizio1  Zappulo Emanuela1  Di Filippo Giovanni1  Sardanelli Alessia1  Tosone Grazia1  Gentile Ivan1  Foggia Maria1  Mercinelli Simona1  Buonomo Antonio Riccardo1  Giaccone Agnese1  Borrelli Francesco1  Lanzardo Amedeo1  Pinchera Biagio1  Conte MariaCarmela Domenica1  Amicone Maria1  Cotugno Mariarosaria1  Piccione Amerigo1  Scotto Riccardo1  Riccardo Scotto2  Biagio Pinchera2  Antonio Riccardo Buonomo2  Ivan Gentile2  Maria Foggia2  Giuseppe Celentano3  Lorenzo Spirito3  Roberto La Rocca3  Lucia Ferreri4  Rosa Carrano4  Stefano Federico4 
[1] ;Department of Clinical Medicine and Surgery, University of Naples “Federico II”, Naples, Italy;Department of Neurosciences, Reproductive and Odontostomatological Sciences, Section of Urology, University of Naples “Federico II”, Naples, Italy;Department of Public Health, University of Naples “Federico II”, Naples, Italy;
关键词: kidney transplant;    SARS-CoV-2;    COVID-19;    transplant;    immunosuppression;   
DOI  :  10.3389/fmed.2022.864865
来源: DOAJ
【 摘 要 】

BackgroundThe COVID-19 pandemic has significantly impacted the management of solid organ transplant recipients and on clinical evolution in post-transplantation. Little is known on the impact of SARS-CoV-2 infection in these patients. The severity and lethality of this disease in solid organ transplant patients are higher thanin the general population. This study aims to describe clinical characteristics of SARS-CoV-2 infection in solid organ transplant recipients followed in our center.MethodsIn this observational study, we enrolled all kidney transplant recipientsattending the A.O.U. Federico II of Naples from March 2020 to January 2021. For each patient we evaluated the epidemiological and clinical characteristics as well as outcome.ResultsWe enrolled 369 kidney transplant patients (229, male, 62%). Of these, 51 (13.8%) acquired SARS-CoV-2 infection and 29 showed symptomatic disease. Of the 51 patients with the infection, 48 (94.11%) had at least one comorbidity and such comorbidities did not constitute a risk factor for a more severe disease. Hospitalization was necessary for 7 (13.7%) patients. Of these, 2 required low-flow oxygen supplementation, 3 non-invasive/high flow ventilation and 2 invasive ventilation. Finally, 2 patients died.ConclusionsOur study shows a lower mortality and hospitalization rate compared to figures available in the literature (4% vs. 13–30% and 14% vs. 32–100%, respectively). Furthermore, the comorbidities examined (hypertension, dyslipidemia, and diabetes) did not constitute a risk factor for a more severe disease condition in this patient category. Further studies with larger sample size are necessary to confirm these data.

【 授权许可】

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