SARS-CoV-2 in Kidney Transplant Recipients: A Systematic Review

Transplantology

Naveen Kumar¹  Mohinder Pal Sachdeva¹  Devinder Singh Rana²  Anurag Gupta²  Rashmi Rana³ 

[1] Department of Anthropology, University of Delhi, Delhi 110007, India;Department of Nephrology, Sir Ganga Ram Hospital, Delhi 110060, India;Department of Research, Sir Ganga Ram Hospital, Delhi 110060, India;

关键词: kidney transplant;    SARS-CoV-2;    COVID-19;    treatment;    vaccination;    transplant;   

DOI  :  10.3390/transplantology3010004

来源: DOAJ

【 摘 要 】

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global healthcare crisis. Kidney transplant (KTx) patients and the patients with chronic kidney disease are two of the most vulnerable populations to the risks of coronavirus disease 2019 (COVID-19). A systematic literature search on PubMed and Web of Science was conducted. We analyzed published case reports, case series and articles on COVID-19’s clinical presentation, management, outcomes and vaccination among kidney transplant recipients. A total of 33 studies were included in the study, which included 1676 KTx recipients and 108 waiting list patients infected with COVID-19. These studies reported the clinical presentation, management and immunosuppressive adjustment among the KTx recipients. The remaining studies focused on other aspects, such as vaccination and transplantation, during the COVID-19 pandemic. Mortality due to COVID-19 was observed to be the highest for KTx recipients, followed by patients on hemodialysis, and lowest in the general population. There is no definitive treatment of COVID-19 yet, and managing transplant patients is enigmatic of this: the treatment is based on symptom management. There is an urgent need for guidelines on managing kidney transplant recipients and immunosuppressive adjustments for the course of COVID-19 treatment.

【 授权许可】

Unknown