Pluripotent Stem Cells for Spinal Cord Injury Repair

Cells

Maria Martin-Lopez¹  Beatriz Fernandez-Muñoz¹  Sebastian Canovas² 

[1] Cellular Reprogramming and Production Unit, Andalusian Network for the Design and Translation of Advanced Therapies, 41092 Sevilla, Spain;Physiology of Reproduction Group, Physiology Department, Mare Nostrum Campus, University of Murcia, 30100 Murcia, Spain;

关键词: tetraplegia;    cell therapy;    animal models;    PSC;    ESC;    iPSC;   

DOI  :  10.3390/cells10123334

来源: DOAJ

【 摘 要 】

Spinal cord injury (SCI) is a devastating condition of the central nervous system that strongly reduces the patient’s quality of life and has large financial costs for the healthcare system. Cell therapy has shown considerable therapeutic potential for SCI treatment in different animal models. Although many different cell types have been investigated with the goal of promoting repair and recovery from injury, stem cells appear to be the most promising. Here, we review the experimental approaches that have been carried out with pluripotent stem cells, a cell type that, due to its inherent plasticity, self-renewal, and differentiation potential, represents an attractive source for the development of new cell therapies for SCI. We will focus on several key observations that illustrate the potential of cell therapy for SCI, and we will attempt to draw some conclusions from the studies performed to date.

【 授权许可】

Unknown