Optimal Tolerogenic Dendritic Cells in Type 1 Diabetes (T1D) Therapy: What Can We Learn From Non-obese Diabetic (NOD) Mouse Models?

Frontiers in Immunology

Lenka Palová-Jelínková¹  Radek Špíšek¹  David P. Funda²  Alena Fajstová²  Jaroslav Goliáš²  Zuzana Kroulíková²  Tomáš Hudcovic² 

[1] Department of Immunology, 2nd Medical School, Charles University, Prague, Czechia;Institute of Microbiology of the Czech Academy of Sciences, v.v.i., Prague, Czechia;SOTIO a s., Prague, Czechia;

关键词: type 1 diabetes;    cell therapy;    animal models;    tolerogenic dendritic cells;    NOD mouse;    protocol optimization;   

DOI  :  10.3389/fimmu.2019.00967

来源: DOAJ

【 摘 要 】

Tolerogenic dendritic cells (tolDCs) are explored as a promising standalone or combination therapy in type 1 diabetes (T1D). The therapeutic application of tolDCs, including in human trials, has been tested also in other autoimmune diseases, however, T1D displays some unique features. In addition, unlike in several disease-induced animal models of autoimmune diseases, the prevalent animal model for T1D, the NOD mouse, develops diabetes spontaneously. This review compares evidence of various tolDCs approaches obtained from animal (mainly NOD) models of T1D with a focus on parameters of this cell-based therapy such as protocols of tolDC preparation, antigen-specific vs. unspecific approaches, doses of tolDCs and/or autoantigens, application schemes, application routes, the migration of tolDCs as well as their preventive, early pre-onset intervention or curative effects. This review also discusses perspectives of tolDC therapy and areas of preclinical research that are in need of better clarification in animal models in a quest for effective and optimal tolDC therapies of T1D in humans.

【 授权许可】

Unknown