Echocardiographic Pulmonary Artery Systolic Pressure in the Coronary Artery Risk Development in Young Adults (CARDIA) Study: Associations With Race and Metabolic Dysregulation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Meng Xu¹  Henrique Doria De Vasconcellos²  Chike Nwabuo²  Joao A. C. Lima²  Henrique T. Moreira²  Anna R. Hemnes³  Deepak K. Gupta⁴  Jeffrey J. Carr⁴  Evan L. Brittain⁴  James G. Terry⁴ 

[1] Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN;Division of Cardiology, Johns Hopkins Hospital, Baltimore, MD;Division of Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN;Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University Medical Center, Nashville, TN;

关键词: adipose tissue;    echocardiography;    inflammation;    metabolic syndrome;    pulmonary hypertension;   

DOI  :  10.1161/JAHA.116.005111

来源: DOAJ

【 摘 要 】

BackgroundThe determinants of pulmonary artery systolic pressure (PASP) are not fully understood. It is unknown whether racial differences in PASP exist or if other population characteristics are associated with pulmonary pressure in humans. We examined echocardiographically estimated PASP in the Coronary Artery Risk Development in Young Adults (CARDIA) study, a middle‐aged, biracial community‐based cohort. Methods and ResultsAt the CARDIA year‐25 examination, 3469 participants underwent echocardiography, including measurement of tricuspid regurgitant jet velocity to estimate PASP. Clinical features, laboratory values, pulmonary function tests, and measurement of adipose depot volume were analyzed for association with PASP. PASP was estimated in 1311 individuals (61% female, 51% white). Older age, higher blood pressure, and higher body mass index were associated with higher PASP. Black race was associated with higher PASP after adjustment for demographics and left and right ventricular function (β 0.94, 95% CI 0.24‐1.64; P=0.009), but this association was no longer significant after further adjustment for lung volume (β 0.42, 95% CI −0.68 to 0.96; P=0.74). Insulin resistance, inflammation (C‐reactive protein and interleukin‐6), and visceral adipose volume were independently associated with higher PASP after adjustment for relevant covariates. PASP rose with worsening diastolic function (ratio of early transmitral Doppler velocity to average mitral annular tissue Doppler velocity [E/e′] and left atrial volume index). ConclusionsIn a large biracial cohort of middle‐aged adults, we identified associations among black race, insulin resistance, and diastolic dysfunction with higher echocardiographically estimated PASP. Further studies are needed to examine racial differences in PASP and whether insulin resistance directly contributes to pulmonary vascular disease in humans.

【 授权许可】

Unknown