Recently Discovered Adipokines and Cardio-Metabolic Comorbidities in Childhood Obesity

International Journal of Molecular Sciences

Gloria Maria Barraco¹  Rosa Luciano²  Michela Semeraro¹  Pedro L. Prieto-Hontoria³  Melania Manco¹ 

[1] Research Unit for Multi-Factorial Diseases, Obesity and Diabetes, Scientific Directorate, Bambino Gesù Children Hospital, Rome 00146, Italy; E-Mails:;Department of Laboratory Medicine, Bambino Gesù Children Hospital, Rome 00146, Italy; E-Mail:;Faculty of Health and Physical Activity Science, University (SEK), Santiago de Chile, Chile; E-Mail:

关键词: adipose tissue;    adipokines;    cardiovascular disease;    childhood obesity;    inflammation;    metabolic syndrome;   

DOI  :  10.3390/ijms151119760

来源: mdpi

【 摘 要 】

White adipose tissue (WAT) asset, in terms of cell number, fat storage capacity and endocrine function, is largely determined in early stages of life and is pivotal for shaping the WAT pro-inflammatory behavior. WAT derived adipokines have been shown to play a main role in several cardio-metabolic abnormalities of obesity. This review focuses on the most recently identified adipokines, namely adipocyte-fatty acid-binding protein, chemerin, fibroblast growth factor-21, lipocalin-2, omentin-1 and vaspin; their role in the pathogenesis of obesity and associated cardio-metabolic abnormalities; and on their adaptive response to body weight change. Evidence consistently suggests a pathogenic role for A-FABP, chemerin and FGF-21. Nevertheless, large population studies are needed to verify whether they can be useful to predict the risk of cardio-metabolic abnormalities in adulthood and/or monitor the clinical response to therapeutic interventions.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.