Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy

Biomedicine & Pharmacotherapy

R. Dhanya¹ 

[1] Cardiovascular Diseases and Diabetes Biology Division, Rajiv Gandhi Centre for Biotechnology (RGCB), Thycaud Post, Poojappura, Trivandrum 695014, Kerala, India;

关键词: Quercetin;    Hyperglycemia;    Reactive oxygen species;    Diabetes;    Oxidative stress;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Quercetin, a bioflavonoid abundant in grapefruit, onion, berries, etc., has vast therapeutic potential, especially against Type 2 diabetes and its complications. Quercetin showed similar effects as that of metformin, (widely prescribed antidiabetic drug) in cell lines models (Sajan et al., 2010; Dhanya et al., 2017). In vivo findings also showcase it as a promising agent against diabetes and its pathophysiological complications. Scope and approach: Quercetin can be produced on a large scale through a novel fermentation-based glycosylation strategy from cheap substrates and can be utilized as a dietary supplement. The review focuses on the mounting evidence pointing to Quercetin as a promising candidate for managing type 2 diabetes and its oxidative stress mediated pathophysiological complications. Conclusion: Quercetin acts on multiple targets of diabetes and regulates key signalling pathways which improve the symptoms as well as the complications of Type 2 diabetes. However further studies are needed to improve the bioavailability and to establish a dosing regimen for Quercetin.

【 授权许可】

Unknown