Utilizing an integrated tri-layered scaffold with Titanium-Mesh-Cage base to repair cartilage defects of knee in goat model

Materials & Design

Qiang Zuo¹  Xiao Zhang²  Chenjun Zhai³  Kai Shen³  Jun Chen³  Jinchun Zhou³  Weimin Fan³  Hao Fei³  Chunyang Luo³ 

[1] Department of Orthopedics, Yixing People's Hospital, Yixing, Jiangsu 214200, China;Department of Orthopedics, Yixing People's Hospital, Yixing, Jiangsu 214200, China;Department of Orthopedics, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China;

关键词: Articular cartilage;    Titanium;    Tissue engineering;    3D printing;    Composite scaffold;   

DOI  :  

来源: DOAJ

【 摘 要 】

The application of multilayered monolithic scaffolds to repair osteochondral defects has become a hot research topic due to the advantage of simulating native osteochondral physiological structure. However, it was difficult to promote proliferation and migration of different kinds of cells in the corresponding layers under the same culture condition. Besides, the methods utilized in previous researches to construct tissue-engineered osteochondral construct were time-consuming, laborious, complicated, costly and difficult to ensure the quality and integration of multilayered construction. Inspired by the application of titanium mesh cage (TMC) for bone graft in spinal fusion surgery, we attempt to 3D print an integrated tri-layered scaffold with Titanium-Mesh-Cage base which could be filled with autogenous cancellous bone for bone graft to the osteochondral defect. Finally, the results of repairing cartilage defects of knee with this scaffold in goat model were evaluated. The results of in-vivo experiments suggested that utilizing the integrated tri-layered scaffold with Titanium-Mesh-Cage base to repair osteochondral defect was a convenient, cost-effective and time-saving procedures, which could achieve a satisfactory repair result as good as that of Mosaicplasty.

【 授权许可】

Unknown