Cyclocurcumin from Curcuma longa selectively inhibits shear stress-induced platelet aggregation

Journal of Functional Foods

Kyung-Min Lim¹  Ok-Nam Bae²  Gwang-Jin An³  Keunyoung Kim³  Yiying Bian³  Thien Ngo³  Jin-Ho Chung³ 

[1] College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of Korea;College of Pharmacy, Hanyang University, Ansan, Gyeonggido 15588, Republic of Korea;College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea;

关键词: Cyclocurcumin;    Curcumin;    SIPA;    Antiplatelet;    Antithrombotic;    Cardiovascular disease;   

DOI  :  

来源: DOAJ

【 摘 要 】

Curcuma longa (C. longa) has been the subject of intensive research for pleiotropic therapeutic potential. However, except for curcumin, the biological activities of other active ingredients of C. longa are not well known. Here, we demonstrated that C. longa extract significantly attenuated shear stress-induced platelet aggregation and cyclocurcumin exhibited the most potent activity (IC50 of 6.33 ± 3.29 μM). Cyclocurcumin potently inhibited shear stress-induced platelet activation, primarily through modulating the initial step, vWF – platelets GP Ib interaction. Moreover, cyclocurcumin effectively inhibited thrombus formation, without influencing platelet cell viability or blood clotting time. Collectively, we demonstrated that cyclocurcumin might be a promising therapeutic agent for the treatment or prevention of thrombotic diseases.

【 授权许可】

Unknown