Overcome the barriers of the skin: exosome therapy

Biomaterials Research

Hyo Jin Kang¹  Hi-Jin You²  Kyoung Ho Lee³  Sang Hyun An³  Yoon Bum Lee³  Hojun Jeon⁴  Gi Hoon Yang⁴  Donggu Kang⁴  Eunjeong Choi⁴  Yoonju Nam⁴ 

[1] Biomedical Research Center, Korea University Ansan Hospital;Department of Plastic Surgery, Korea University Ansan Hospital;Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF);Research Institute of Additive Manufacturing and Regenerative Medicine, Baobab Healthcare Inc.;

关键词: Exosomes;    Biomarker;    Skin defects;    Skin treatment;   

DOI  :  10.1186/s40824-021-00224-8

来源: DOAJ

【 摘 要 】

Abstract Exosomes are nano-sized cargos with a lipid bilayer structure carrying diverse biomolecules including lipids, proteins, and nucleic acids. These small vesicles are secreted by most types of cells to communicate with each other. Since exosomes circulate through bodily fluids, they can transfer information not only to local cells but also to remote cells. Therefore, exosomes are considered potential biomarkers for various treatments. Recently, studies have shown the efficacy of exosomes in skin defects such as aging, atopic dermatitis, and wounds. Also, exosomes are being studied to be used as ingredients in commercialized skin treatment products. In this review, we discussed the need for exosomes in skin therapy together with the current challenges. Moreover, the functional roles of exosomes in terms of skin treatment and regeneration are overviewed. Finally, we highlighted the major limitations and the future perspective in exosome engineering.

【 授权许可】

Unknown