Overcome the barriers of the skin: exosome therapy

Biomaterials Research

Hyo Jin Kang¹  Hi-Jin You²  Sang Hyun An³  Kyoung Ho Lee³  Yoon Bum Lee³  Gi Hoon Yang⁴  Donggu Kang⁴  Hojun Jeon⁴  Yoonju Nam⁴  Eunjeong Choi⁴ 

[1] Biomedical Research Center, Korea University Ansan Hospital, 123 Jeokgeum-ro, Danwon-gu, 15355, Ansan-si, Gyeonggi-Do, South Korea;Department of Plastic Surgery, Korea University Ansan Hospital, 123 Jeokgeum-ro, Danwon-gu, 15355, Ansan-si, Gyeonggi-Do, South Korea;Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), 80 Cheombok-ro, Dong-gu, 41061, Daegu, South Korea;Research Institute of Additive Manufacturing and Regenerative Medicine, Baobab Healthcare Inc., 55 Hanyangdaehak-Ro, 15588, Ansan-si, Gyeonggi-Do, South Korea;

关键词: Exosomes;    Biomarker;    Skin defects;    Skin treatment;   

DOI  :  10.1186/s40824-021-00224-8

来源: Springer

【 摘 要 】

Exosomes are nano-sized cargos with a lipid bilayer structure carrying diverse biomolecules including lipids, proteins, and nucleic acids. These small vesicles are secreted by most types of cells to communicate with each other. Since exosomes circulate through bodily fluids, they can transfer information not only to local cells but also to remote cells. Therefore, exosomes are considered potential biomarkers for various treatments. Recently, studies have shown the efficacy of exosomes in skin defects such as aging, atopic dermatitis, and wounds. Also, exosomes are being studied to be used as ingredients in commercialized skin treatment products. In this review, we discussed the need for exosomes in skin therapy together with the current challenges. Moreover, the functional roles of exosomes in terms of skin treatment and regeneration are overviewed. Finally, we highlighted the major limitations and the future perspective in exosome engineering.

【 授权许可】

CC BY