Traces pilot pharmacokinetic study dataset

Data in Brief

F. Loingeville¹  AS. Ducloy-Bouthors²  M. Jeanne³  G. Lebuffe⁴  P. Odou⁵  S. Gilliot⁵  B. Hennart⁵ 

[1] CHU Lille, Pôle anesthésie-réanimation, maternité Jeanne de Flandre, F-59000 Lille, France;Corresponding author.;CHU Lille, Unité fonctionnelle de toxicologie, centre biologie pathologie, F-59000 Lille, France;Univ. Lille, CHU Lille, EA 2694 - Santé publique: épidémiologie et qualité des soins, F-59000 Lille, France;Univ. Lille, ULR 7365 – GRITA - Groupe de Recherche sur les formes Injectables et les Technologies Associées, F-59000 Lille, France;

关键词: Caesarean section;    Intravenous;    Pharmacokinetics;    Postpartum haemorrhage;    Tranexamic acid;   

DOI  :  

来源: DOAJ

【 摘 要 】

The dataset displays the pharmacokinetics data obtained from the TRACES pilot study. The nine patients included were undergoing haemorrhagic caesarean section (blood loss > 800 mL) and receiving a single i.v dose of tranexamic acid (0.5, 1 or 2 g over 1 min).The dataset gathers the tranexamic acid blood and urinary concentrations. With these first elements, a pharmacokinetic compartment model was built as described in Gilliot et al. and the individual pharmacokinetic parameters were estimated. In parallel, the patients anthropometric, biological, and clinical characteristics were collected. The correlation between the patient data and the estimated individual pharmacokinetic parameters were tested.The correlation tests revealed that the dose, the height, the body weight, and the ideal bodyweight had and impact on the volume of distribution of tranexamic acid. According to these results, these latter covariates were explored using a multi-regression analysis in Gilliot et al.

【 授权许可】

Unknown