Antitumor Activity and Physicochemical Properties of New Thiosemicarbazide Derivative and Its Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) Complexes

Molecules

Paweł Szymański¹  Kamila Czarnecka¹  Monika Pitucha²  Alina Climova³  Bartłomiej Rogalewicz³  Ekaterina Pivovarova³  Agnieszka Czylkowska³  Małgorzata Szczesio³  Jarosław Sukiennik³  Katarzyna Gas⁴  Maciej Sawicki⁴ 

[1] Department of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151 Lodz, Poland;Independent Radiopharmacy Unit, Faculty of Pharmacy, Medical University of Lublin, PL-20093 Lublin, Poland;Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland;Institute of Physics, Polish Academy of Sciences, Aleja Lotnikow 32/46, PL-02668 Warsaw, Poland;

关键词: thiosemicarbazides;    metal complexes;    A549 cancer cells;    antitumor activity;    biological activity;    thermogravimetric analysis;   

DOI  :  10.3390/molecules27092703

来源: DOAJ

【 摘 要 】

A novel biologically active thiosemicarbazide derivative ligand L (N-[(phenylcarbamothioyl)amino]pyridine-3-carboxamide) and a series of its five metal(II) complexes, namely: [Co(L)Cl₂], [Ni(L)Cl₂(H₂O)], [Cu(L)Cl₂(H₂O)], [Zn(L)Cl₂] and [Cd(L)Cl₂(H₂O)] have been synthesized and thoroughly investigated. The physicochemical characterization of the newly obtained compounds has been performed using appropriate analytical techniques, such as ¹H and ^l3C nuclear magnetic resonance (NMR), inductively coupled plasma (ICP), thermogravimetric analysis (TGA), Fourier-transform infrared spectroscopy (FTIR) and magnetic measurements. In order to study the pharmacokinetic profile of the compounds, ADMET analysis was performed. The in vitro studies revealed that the synthesized compounds exhibit potent biological activity against A549 human cancer cell line.

【 授权许可】

Unknown