Synthesis of 2-(2-R1-Hydrazino)-5-(R2-benzyl)-2-thiazolines on the Basis of Meerweins Arylation Products of Allyl Isothiocyanate

Molecules

Volodymyr V. Karpyak²  Mykola D. Obushak¹ 

[1] id="af1-molecules-08-00263">Department of Organic Chemistry, Ivan Franko Lviv National University, Kyryla & Mefodiya St. 6, Lviv 79005, Ukrain

关键词: Arylation;    allyl isothiocyanate;    thiosemicarbazides;    2-thiazolines;    cyclizations;   

DOI  :  10.3390/80200263

来源: mdpi

【 摘 要 】

3-Aryl-2-chloropropylisothiocyanates (1) are formed by interaction of arene-diazonium chlorides with allyl isothiocyanate. Adducts 1 react with monoacylhydrazines to form 1-acyl-4-(3-aryl-2-chloropropyl)thiosemicarbazides (2a–d). Thiosemicarbazides 2a–d in the presence of bases selectively transform into 2-(2-R¹-hydrazino)-5-(R²-benzyl)-2-thiazolines (3a–d).

【 授权许可】

Unknown   
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