Seleno-lentinan prevents chronic pancreatitis development and modulates gut microbiota in mice

Journal of Functional Foods

Min Yu¹  Yu Wang²  Xiuhong Xu³  Juanjuan Qu³  Yang Hu³  Koukou Li³  Guangming Ren³ 

[1] Drug Safety Evaluation Center, Heilongjiang University of Chinese Medicine, Harbin 150040, China;Harbin Center for Disease Control and Prevention, Harbin 150056, China;Resources and Environmental College, Northeast Agricultural University, Harbin 150030, China;

关键词: Seleno-lentinan;    Chronic pancreatitis;    16S rRNA;    High throughput sequencing;    Gut microbiota;   

DOI  :  

来源: DOAJ

【 摘 要 】

The ability of seleno-lentinan in preventing chronic pancreatitis was examined and its prebiotic-like efficacy on gut microbiota in mice induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine was also investigated. Seleno-lentinan more effectively impeded the progress of inflammation and fibrosis than selenite and lentinan through the enhancement of superoxide dismutase and glutathione peroxidase activities, inhibiting lipid peroxidation and decreasing the levels of serum tumour necrosis factor-α and interleukin-1β, as well as pancreatic hydroxyproline. The high throughput sequencing analysis showed that seleno-lentinan increased the relative abundance of Bacteroidetes, whereas it decreased that of Firmicutes. At the genus level, seleno-lentinan increased the proportion of beneficial bacteria such as Lactobacillus, Bacteroides, Prevotella, and Roseburia. Besides, the supplementation of selenium had a beneficial impact on the proliferation of lactic acid bacteria. Thus, seleno-lentinan availably prevents chronic pancreatitis development by elevating antioxidant status and has a prebiotic-like efficacy on the modulation of gut microbiota in mice.

【 授权许可】

Unknown