Antioxidant, Antihypertensive, Hypoglycaemic and Nootropic Activity of a Polyphenolic Extract from the Halophyte Ice Plant (Mesembryanthemum crystallinum)

Foods

Daniel Rico¹  Ana Belén Martín-Diana¹  María Elvira López-Caballero²  Oscar Martínez-Álvarez²  Marta María Calvo² 

[1] Agricultural Technological Institute of Castile and León (ITACyL), Government of Castile and León, Ctra. de Burgos Km. 119, Finca Zamadueñas, 47071 Valladolid, Spain;Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), C/José Antonio Novais 10, 28040 Madrid, Spain;

关键词: ice plant;    polyphenols;    total antioxidant activity;    angiotensin-converting enzyme;    prolyl oligopeptidase;    dipeptidyl peptidase IV;   

DOI  :  10.3390/foods11111581

来源: DOAJ

【 摘 要 】

This study aims to determine the potential antioxidant, antihypertensive, hypoglycaemic and nootropic activity of a purified polyphenolic extract from the halophyte ice plant (Mesembryanthemum crystallinum). The ice plant extract showed good antioxidant activity measured by DPPH, ORAC, TEAC, FRAP and ferrous ion chelating activity. Moreover, the extract showed potent ACE, DPP-IV and PEP-inhibitory activity (90.5%, 98.6% and 73.1%, respectively, at a final concentration of 1 mg/mL). The extract was fractionated and the fraction with the highest content of total phenolic compounds showed the highest bioactivity, suggesting that polyphenols could be mainly responsible for the abovementioned activities. The tentative polyphenol identification by HPLC-ESI-QTOF-MS in this fraction revealed that flavones (>65%) are the major group, with apigenin (38%) predominating, followed by diosmin (17.7%) and luteolin (11.9%). They could presumably be the main elements responsible for the enzymatic inhibition activity. Additionally, 4-hydroxybenzoic acid, p-coumaric acid and a hydroxycinnamic acid derivative (2-O-(p-cumaroyl)-l-malic acid) were found in the extract. To our knowledge, this is the first time that some of these activities have been reported for halophyte extracts.

【 授权许可】

Unknown