Performance in even a simple perceptual task depends on mouse secondary visual areas

eLife

Bradley Akitake¹  Mark H Histed¹  Hannah C Goldbach¹  Caitlin E Leedy¹ 

[1] Unit on Neural Computation and Behavior, National Institute of Mental Health Intramural Program, National Institutes of Health, Bethesda, United States;

关键词: neural circuits;    cerebral cortex;    optogenetics;   

DOI  :  10.7554/eLife.62156

来源: DOAJ

【 摘 要 】

Primary visual cortex (V1) in the mouse projects to numerous brain areas, including several secondary visual areas, frontal cortex, and basal ganglia. While it has been demonstrated that optogenetic silencing of V1 strongly impairs visually guided behavior, it is not known which downstream areas are required for visual behaviors. Here we trained mice to perform a contrast-increment change detection task, for which substantial stimulus information is present in V1. Optogenetic silencing of visual responses in secondary visual areas revealed that their activity is required for even this simple visual task. In vivo electrophysiology showed that, although inhibiting secondary visual areas could produce some feedback effects in V1, the principal effect was profound suppression at the location of the optogenetic light. The results show that pathways through secondary visual areas are necessary for even simple visual behaviors.

【 授权许可】

Unknown