Dose-dependent T-cell Dynamics and Cytokine Cascade Following rVSV-ZEBOV Immunization

EBioMedicine

Hans C. Stubbe¹  Markus Eickmann¹  Michael Spohn¹  Madeleine E. Zinser¹  Nadine Biedenkopf¹  Felix Stahl¹  Alen Jambrecina¹  Rahel Kasonta¹  Sebastian Lunemann¹  Stefan Schmiedel¹  Saskia Borregaard¹  My L. Ly¹  Ansgar W. Lohse¹  Anne Rechtien¹  Marc Lütgehetmann¹  Flaminia Olearo¹  Sarah K. Fehling¹  Thomas Strecker¹  Selidji Todagbe Agnandji²  Claire-Anne Siegrist³  Angela Huttner³  Peter G. Kremsner⁴  Jessica S. Brosnahan⁴  Verena Krähling⁵  Stephan Becker⁵  Patricia Njuguna⁶  Philip Bejon⁶  Sanjeev Krishna⁷  Marylyn M. Addo⁸  Olivier Lapujade⁹  Barbara Savarese⁹  Kayvon Modjarrad⁹  Vasee Moorthy⁹  Patricia Fast⁹  Marie-Paule Kieny⁹ 

[1] ;Centre de Recherches Medicales de Lambaréné, Institut für Tropenmedizin, Universitätsklinikum Tübingen, Gabon, Germany;Geneva University Hospitals, Switzerland;Institut für Tropenmedizin, Universitätsklinikum Tübingen, Germany;Institute of Virology, Marburg, Germany;Kenya Medical Research Institute, Kilifi, Kenya;St George's University of London, UK;University Medical Center Hamburg, Germany;World Health Organization, Geneva, Switzerland;

关键词: rVSV-ZEBOV;    Ebola vaccine;    Phase I study;    T-cell responses;    Cytokines;    Humoral and cell-mediated immune responses;   

DOI  :  10.1016/j.ebiom.2017.03.045

来源: DOAJ

【 授权许可】

Unknown