Ebola vaccine uptake and attitudes among healthcare workers in North Kivu, Democratic Republic of the Congo, 2021

Frontiers in Public Health

Public Health

Elizabeth Song¹  Jasmine Powell¹  Stephanie C. Garbern²  Mohamed F. Jalloh³  Gnakub Norbert Soke⁴  Stephane Hans Bateyi Mustafa⁵  Reena H. Doshi⁶  Dieula Delissaint Tchoualeu⁶  Terri B. Hyde⁶  Shibani Kulkarni⁶  Monica K. Fleming⁶  Neetu Abad⁶  Dimitri Prybylski⁶  David L. Fitter⁶  Hongjiang Gao⁶  Ruth Kallay⁶  Ruffin Mitume Mutumwa⁷  Eta Ngole Mbong⁷  Arsene Balene Ombeni⁷  Rigobert Fraterne Muhayangabo⁷  Shiromi M. Perera⁸  Adam C. Levine⁹  Bailey Glenn^1,10  Giulia Earle-Richardson^1,11  Monique Gainey^1,12 

[1] Brown University, Providence, RI, United States;Department of Emergency Medicine, Brown University, Providence, RI, United States;Division of Global HIV and TB, Centers for Disease Control and Prevention, Atlanta, GA, United States;Division of Global Health Protection, Centers for Disease Control and Prevention, Kinshasa, Democratic Republic of Congo;Expanded Programme on Immunization, Goma, Democratic Republic of Congo;Global Immunization Division, Centers for Disease Control and Prevention, Atlanta, GA, United States;International Medical Corps, Goma, Democratic Republic of Congo;International Medical Corps, Washington, DC, United States;International Medical Corps, Washington, DC, United States;International Medical Corps, Goma, Democratic Republic of Congo;James A. Ferguson Infectious Disease Program, Baltimore, MD, United States;National Center for Emerging and Zoonotic Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States;Rhode Island Hospital, Providence, RI, United States;

关键词: Ebola;    Ebola vaccine;    vaccine hesitancy;    vaccine acceptance;    Democratic Republic of the Congo;    Ebola virus disease (EVD);    vaccines;   

DOI  :  10.3389/fpubh.2023.1080700

 received in 2022-10-26, accepted in 2023-06-19,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionDuring the 2018–2020 Ebola virus disease (EVD) outbreak in the eastern part of the Democratic Republic of the Congo (DRC), prevention and control measures, such as Ebola vaccination were challenging by community mistrust. We aimed to understand perceptions regarding Ebola vaccination and identify determinants of Ebola vaccine uptake among HCWs.MethodsIn March 2021, we conducted a cross-sectional survey among 438 HCWs from 100 randomly selected health facilities in three health zones (Butembo, Beni, Mabalako) affected by the 10th EVD outbreak in North Kivu, DRC. HCWs were eligible if they were ≥ 18 years and were working in a health facility during the outbreak. We used survey logistic regression to assess correlates of first-offer uptake (i.e., having received the vaccine the first time it was offered vs. after subsequent offers).ResultsOf the 438 HCWs enrolled in the study, 420 (95.8%) reported that they were eligible and offered an Ebola vaccine. Among those offered vaccination, self-reported uptake of the Ebola vaccine was 99.0% (95% confidence interval (CI) [98.5–99.4]), but first-offer uptake was 70.2% (95% CI [67.1, 73.5]). Nearly all HCWs (94.3%; 95% CI [92.7–95.5]) perceived themselves to be at risk of contracting EVD. The most common concern was that the vaccine would cause side effects (65.7%; 95% CI [61.4–69.7]). In the multivariable analysis, mistrust of the vaccine source or how the vaccine was produced decreased the odds of first-time uptake.DiscussionOverall uptake of the Ebola vaccine was high among HCWs, but uptake at the first offer was substantially lower, which was associated with mistrust of the vaccine source. Future Ebola vaccination efforts should plan to make repeated vaccination offers to HCWs and address their underlying mistrust in the vaccines, which can, in turn, improve community uptake.

【 授权许可】

Unknown   
Copyright © 2023 Doshi, Garbern, Kulkarni, Perera, Fleming, Muhayangabo, Ombeni, Tchoualeu, Kallay, Song, Powell, Gainey, Glenn, Mutumwa, Hans Bateyi Mustafa, Earle-Richardson, Gao, Abad, Soke, Fitter, Hyde, Prybylski, Levine, Jalloh and Mbong.