Lipid Peroxidation Assessment in Preclinical Alzheimer Disease Diagnosis

Antioxidants

Lourdes Álvarez-Sánchez¹  Consuelo Cháfer-Pericás¹  Carmen Peña-Bautista¹  Inés Ferrer¹  Miguel Baquero¹  Marina López-Nogueroles²  Antonio José Cañada-Martínez³  Jean-Marie Galano⁴  Camille Oger⁴  Thierry Durand⁴ 

[1] Alzheimer’s Disease Research Group, Health Research Institute La Fe, 46026 Valencia, Spain;Analytical Unit Platform, Health Research Institute La Fe, 46026 Valencia, Spain;Data Science Unit, Health Research Institute La Fe (IIS La Fe), 46026 Valencia, Spain;Institut des Biomolécules Max Mousseron, IBMM, University of Montpellier, CNRS, ENSCM, 34093 Montpellier, France;

关键词: Alzheimer disease;    plasma;    biomarker;    lipid peroxidation;    mass spectrometry;    preclinical;   

DOI  :  10.3390/antiox10071043

来源: DOAJ

【 摘 要 】

Alzheimer disease (AD) is an increasingly common neurodegenerative disease, especially in countries with aging populations. Its diagnosis is complex and is usually carried out in advanced stages of the disease. In addition, lipids and oxidative stress have been related to AD since the earliest stages. A diagnosis in the initial or preclinical stages of the disease could help in a more effective action of the treatments. Isoprostanoid biomarkers were determined in plasma samples from preclinical AD participants (n = 12) and healthy controls (n = 31) by chromatography and mass spectrometry (UPLC-MS/MS). Participants were accurately classified according to cerebrospinal fluid (CSF) biomarkers and neuropsychological examination. Isoprostanoid levels did not show differences between groups. However, some of them correlated with CSF biomarkers (t-tau, p-tau) and with cognitive decline. In addition, a panel including 10 biomarkers showed an area under curve (AUC) of 0.96 (0.903–1) and a validation AUC of 0.90 in preclinical AD prediction. Plasma isoprostanoids could be useful biomarkers in preclinical diagnosis for AD. However, these results would require a further validation with an external cohort.

【 授权许可】

Unknown