Unfolding the pathogenesis of systemic sclerosis through epigenomics

STEMedicine

Ying Xiao¹  Xiuzhi Jia¹  Hao Cheng² 

[1] Central Lab of Biomedical Research Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China;Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China;

关键词: Epigenetics;    Methylation;    Histone modification;    microRNA;    Systemic sclerosis;   

DOI  :  10.37175/stemedicine.v1i1.5

来源: DOAJ

【 摘 要 】

As a group of autoimmune diseases, systemic sclerosis (scleroderma, SSc) is characterized by immune dysregulation, micro-vessels dominant obliteration, and the final fibrosis of the skin and or internal organs. Although the precise mechanisms are still unknown, increasing data shows that epigenetic mechanisms, such as DNA methylation, histone modification, and microRNA (miRNA), are strictly related to the pathogenesis of scleroderma. Epigenetic mechanisms, which can link genetics and environmental stress, represents a promising field in systemic sclerosis investigation. The objective of this review is, to sum up the current information about epigenetic alteration.

【 授权许可】

Unknown