Anti-inflammatory Effect of Phytoncide in an Animal Model of Gastrointestinal Inflammation

Molecules

Azra Memon¹  Yuliya Pyao¹  WoonKyu Lee¹  Yeong-Geun Lee²  SeChan Kang²  Se-eun Kim²  BaeYong Kim³ 

[1] Department of Biomedical Sciences, School of Medicine, Inha University, Incheon 22212, Gyeonggi, Korea;Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University, Yongin-si 17104, Gyeonggi-do, Korea;Research Institute, Phylus Co., LTD., Danyang-gun 27000, Chungcheongbuk-do, Korea;

关键词: Pinus koraiensis;    phytoncide;    anti-inflammation;    gastritis;    colitis;   

DOI  :  10.3390/molecules26071895

来源: DOAJ

【 摘 要 】

Background:Phytoncide is known to have antimicrobial and anti-inflammatory properties. Purpose: This study was carried out to confirm the anti-inflammatory activity of two types of phytoncide extracts from pinecone waste. Methods: We made two types of animal models to evaluate the efficacy, an indomethacin-induced gastroenteritis rat model and a dextran sulfate sodium-induced colitis mouse model. Result: In the gastroenteritis experiment, the expression of induced-nitric oxide synthase (iNOS), a marker for inflammation, decreased in the phytoncide-supplemented groups, and gastric ulcer development was significantly inhibited (p < 0.05). In the colitis experiment, the shortening of the colon length and the iNOS expression were significantly suppressed in the phytoncide-supplemented group (p < 0.05). Conclusions:Through this study, we confirmed that phytoncide can directly inhibit inflammation in digestive organs. Although further research is needed, we conclude that phytoncide has potential anti-inflammatory properties in the digestive tract and can be developed as a functional agent.

【 授权许可】

Unknown