In Vivo Positive Magnetic Resonance Imaging of Brain Cancer (U87MG) Using Folic Acid-Conjugated Polyacrylic Acid-Coated Ultrasmall Manganese Oxide Nanoparticles

Applied Sciences

Kwon-Seok Chae¹  AbdullahKhamis Ali Al Saidi²  MohammadYaseen Ahmad²  Dejun Zhao²  Ying Liu²  Shanti Marasini²  Gang-Ho Lee²  Huan Yue²  Son-Long Ho²  Shuwen Liu²  Tirusew Tegafaw²  Hyunsil Cha³  Yongmin Chang³  Ji-Ung Yang⁴  Ji-Ae Park⁴  Soyeon Kim⁴ 

[1] Department of Biology Education, Teachers’ College, Kyungpook National University, Taegu 41566, Korea;Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Korea;Department of Molecular Medicine, School of Medicine, Kyungpook National University, Taegu 41944, Korea;Division of Applied RI, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 01812, Korea;

关键词: brain cancer;    cancer targeting;    folic acid;    magnetic resonance imaging;    ultrasmall manganese oxide nanoparticles;   

DOI  :  10.3390/app11062596

来源: DOAJ

【 摘 要 】

Ultrasmall nanoparticles are potential candidates for application as high-performance imaging agents. Herein, we present the synthesis and characterization of folic acid (FA)-conjugated polyacrylic acid (PAA)-coated MnO nanoparticles with an average particle diameter of 2.7 nm. FA conferred cancer-targeting ability, while PAA conferred good colloidal stability and low cellular cytotoxicity on the FA-PAA-coated MnO nanoparticles. Further, the nanoparticles exhibited a high relaxivity (r₁) value of 9.3 s⁻¹mM⁻¹ (r₂/r₁ = 2.2). Their application potential as cancer-targeting T₁ magnetic resonance imaging contrast agents was confirmed by their enhanced T₁ contrast enhancements at the brain cancer (U87MG) site upon intravenous administration to mice tails.

【 授权许可】

Unknown